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Sun H, Jiang H, Eliaz A, Kellum JA, Peng Z, Eliaz I. Galectin-3 in septic acute kidney injury: a translational study. Crit Care. 2021 Mar 18;25(1):109. DOI: 10.1186/s13054-021-03538-0. PMID: 33736691. PMCID: PMC7977587. Another significant study investigated the role of Gal-3 as a driver of oxidative stress in human cardiac fibroblasts, spontaneously hypertensive animal models and human aortic stenosis tissue. Results showed Gal-3 downregulates the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts, uncovering a new pathway whereby Gal-3 fuels cardiac damage. Importantly, MCP treatment restored cardiac Prx-4 and improved oxidative status. 3 PectaSol-C is the most advanced and effective Modified Citrus Pectin (MCP) supplement available. Gentle and highly effective formula, extensive scientific research has shown that PectaSol-C MCP can: Z.Y. Zhao, et al., “The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized with Toxic Lead Levels,” Altern. Ther. Health Med. 14(4), 34–38 (2008). Additional inflammatory conditions, including liver and kidney disease, arthritis, obesity, neurodegeneration and infection have all shown a significant reduction by this researched form of MCP.
October 29, 2021 Dr. Michael Ruscio, DC is a clinician, Naturopathic Practitioner, clinical researcher, author, and adjunct professor at the University of Bridgeport. His work has been published in peer-reviewed medical journals and he speaks at conferences around the globe. Modified Citrus Pectin Benefits for Heavy Metal Detox and Beyond Studies on the effect of pectin in myeloma therapy are ongoing. Alkali-soluble pectin reduces immunoglobulin E (IgE) production in human myeloma cell line U266 in a study examining the effects of water- (WP), hexametaphosphate- (HXP), acid- (HP), and alkali-soluble (OHP) pectin solutions. However, whereas OP altered cell viability, WP, HXP, and HP did not. Moreover, pectin increased the proportion of IL-2 receptor (IL-2R)-positive cells in mesenteric lymph node (MLN) lymphocytes, indicating that its immunoglobulin modifying effect was mediated by activated Th1 cells [ 58].There were also no negative side effects observed in a clinical trial involving children with lead toxicity in China. For three months, the hospitalized children between the ages of 5 and 12 were given 15 g of MCP in three divided doses a day [ 4]. Mariño KV, Cagnoni AJ, Croci DO, Rabinovich GA. Mariño KV, et al. Nat Rev Drug Discov. 2023 Apr;22(4):295-316. doi: 10.1038/s41573-023-00636-2. Epub 2023 Feb 9. Nat Rev Drug Discov. 2023. PMID: 36759557 Review. Suggested Use:As a dietary supplement, for maximum support, take one 5 gram scoop 3 times daily with liquid on any empty stomach. For long term maintenance, take one 5 gram scoop daily with liquid on an empty stomach. The pectin found in many fruits cannot be absorbed into the bloodstream due to its large molecular size. Only PectaSol-C MCP is produced using a proprietary process that carefully controls the weight and structure of the pectin molecules. The result is Modified Citrus Pectin with a specific low molecular weight range less than 15 kilodaltons and a low degree of esterification. This means that it is readily and effectively absorbed into the bloodstream, where it can actively promote cellular wellness.
Induced mitochondrial depolarization, reactive oxygen species generation, caspase-3 and Poly (ADP-ribose) polymerase 1 (PARP1) activation resulting in DNA fragmentation. For best results, take PectaSol at an active dose of 15 grams per day. Active dose (max. level support) is 5 grams three times per day. Maintenance dose (min. level support) is 5 grams one time per day. L. Calvier, et al., “The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries,” JACC Heart Fail. 3(1), 59–67 (2015). PectaSol® Metal Detox has been clinically studied to support safe heavy metal toxin and radioactive particle removal from the body, and is formulated to provide additional support to prevent toxin reabsorption and redistribution through the gut wall.* In 2018, for example, clinical results from an ongoing multicentre trial on this form of MCP in biochemically relapsed prostate cancer were presented at the American Society for Clinical Oncology Genitourinary Conference. Reported in the Journal of Clinical Oncology, the study — “Effects of Pectasol-C Modified Citrus Pectin Treatment on PSA Dynamics in Non-Metastatic Biochemically Relapsed Prostate Cancer Patients” — demonstrated the ability of the only researched form of MCP to significantly slow PSA doubling time and halt disease progression in the majority of subjects. 1 What is galectin-3 (Gal-3)?
The observations of PSA stabilization/response and lengthening of PSADT in patients treated with P-MCP are consistent with prior preclinical and clinical data. The extracellular galectin-3 protein participates in the tumorigenesis process by various mechanisms, including inflammation, cellular proliferation, angiogenesis, and progression to an overt metastatic state via cancer cell–endothelial adhesion in distant organs. Elevated galectin-3 serum level was reported in prostate cancer patients [ 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. P-MCP is an oral competitive inhibitor of galectin-3, and preliminary preclinical and clinical data suggest that it is active in patients with prostate cancer [ 17, 18]. A subgroup analysis of the PSADT risk grouping ( Table 1 and Table 2) revealed a significant change of median PSADT after P-MCP therapy (versus baseline) in patients with good (median PSADT 20.4 versus 14.7 months, p = 0.0006) and intermediate (6.5 versus 5.21 months, p = 0.0025) risk.
In my clinical experience, those with mycotoxicity (mold toxicity) often have trouble tolerating modified citrus pectin. This may be because MCP has the ability to bind to mycotoxins (like it binds to and removes metals), which could then lead to increased symptoms as the toxins are being released.
A further study used Wistar DMH-treated rats to explore how AP formulations affect neoplastic damage and proliferative marker dysregulation, finding a substantial beneficial effect on colon carcinogenesis through the regulation of physiological indicators, oxidative stress, inflammatory markers, and hemodynamic alterations [ 26]. The anti-cancer activities of phenolics from apple trash have also been studied in HT29, HT115, and CaCo-2 cell lines as in vitro models of colon carcinogenesis. They found a significant decrease in HT115 cell invasion when apple phenolics were used to prevent DNA damage, a process associated with tumor initiation. In addition, hydrogen peroxide (H 2O 2)-induced damage was significantly reduced in HT29 cells, and CaCo-2 cell barrier function was increased, a process associated with reduced tumor promotion and metastatic potential [ 27]. A cohort size of sixty patients provided 85% statistical power was used to evaluate the decrease in PSA progression rate at six months, from 80% (reported data about the natural history of PSA dynamics without active therapy) [ 4] to 40% (with P-MCP therapy), and PSADT improvement (lengthening) rate from 25% (reported natural history without active treatment) [ 19] to 50% (with P-MCP therapy). Extracellular Gal-3 acts as an adhesion surface protein, forming lattices with itself, binding glycoproteins and glycolipid membrane receptors and creating a gel-like biofilm that anchors other procancerous growth factors and inflammatory compounds within the extracellular matrix. George T, Brady MF. Ethylenediaminetetraacetic Acid (EDTA). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 33351441.
The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification. Other Ingredients: Vegetable capsule (natural vegetable cellulose, water), vegetable stearic acid, magnesium stearate, microcrystalline cellulose, silicon dioxide.Other research studies show how MCP eliminates heavy metals, like mercury and lead, from the body. There are five studies of MCP in humans (where it is used alone or with green algae) showing its ability togreatly reduce the levelof heavy metals in the body. For example,one study (6) showed it encouraged the excretion of heavy metals like chromium, lead and arsenic from the body. Modified citrus pectin may act as a natural chelating agent, helping to remove excess heavy metals from the body. Using MCP for heavy metal detoxification is appealing due to the fact that it may have fewer side effects and be less invasive than other types of chelation therapy. The American Cancer Society states that ’Severalanimal studies found that MCP helped reduce the spread of prostate, breast, and skin cancer. Animals with these types of cancer that were fed MCP had a much lower risk of the tumor spreading to the lungs’. Circulating Gal-3 is often substantially elevated in patients with cancer, particularly metastatic cancer. Because of its primary roles in cancer formation and progression, Gal-3 has been termed “the guardian of the tumour microenvironment.” 6
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