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BV has been shown to have anti-inflammatory, antinociceptive, antioxidant, and anti-apoptotic properties and has been shown to alter gene expression and fibrosis ( 81– 84). Side effects include proinflammation [higher doses of PLA2, mast cell degranulating peptides, hemolytic compounds (melittin)], allergic reactions to protease inhibitors and peptides, anaphylactic responses and death ( 76). Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. (2017) 140:335–48. doi: 10.1016/j.jaci.2017.06.003 Youngren-Ortiz SR, Chougule MB, Morris KR. Development and evaluation of siRNA loaded gelatin nanocarriers for the treatment of asthma. Dissertations and Theses. University of Hawaii at Hilo. (2016) Available online at: Additionally, venom immunotherapy, in which bee venom is administered by a healthcare professional by injection — is used to treat people with severe allergies to bee stings.

Based on the available research, it’s safe to say that adverse reactions — ranging from mild to potentially fatal — are common when using bee venom. For this reason, you should exercise extreme caution when using these products or treatments. Additionally, it contains phospholipase A2, an enzyme and major allergen that causes inflammation and cell damage. Nevertheless, according to some research, the enzyme may also have anti-inflammatory and immunoprotective effects ( 4, 5). ErŽen R, Košnik M, Šilar M, Korošec P. Basophil response and the induction of a tolerance in venom immunotherapy: along term sting challenge study. Allergy. (2012) 67:822–30. doi: 10.1111/j.1398-9995.2012.02817.x Waziri B, Alhaji UI, Oduwale MA, Umar HI, Abdulmalik AM. A rare concurrence: bee venom associated acute tubular necrosis and acute interstitial nephritis. Oxf Med Case Reports 2022;5:167-70. View abstract.

Caldwell JR. Venoms, copper, and zinc in the treatment of arthritis. Rheum Dis Clin North Am 1999;25:919-28. View abstract. Good product, but pricy if not on offer. Seems to work, but be aware that it could create a reaction if allergic to bee stings.” Jakob T, Rauber MM, Perez-Riverol A, Spillner E, Blank S. The honeybee venom major allergen Api m 10 (Icarapin) and its role in diagnostics and treatment of hymenoptera venom allergy. Curr Allergy Asthma Rep. (2020) 20:48. doi: 10.1007/s11882-020-00943-3 Memariani H, Memariani M, Moravvej H, Shahidi-Dadras M. Melittin: a venom-derived peptide with promising anti-viral properties. Eur J Clin Microbiol Infect Dis. (2020) 39:5–17. doi: 10.1007/s10096-019-03674-0 Baek YH, Huh JE, Lee JD, Choi DY, Park DS. Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: mediation by α2-Adrenoceptors. Brain Res. (2006) 1073–1074:305–10. doi: 10.1016/j.brainres.2005.12.086

An 8-week study in 120 people with RA found that bee-venom acupuncture, which employed 5–15 bee stings every other day, provided symptom relief effects that were similar to those of traditional RA medications like Methotrexate and Celecoxib ( 12). Roy A, Bharadvaja N. Venom-derived bioactive compounds as potential anticancer agents: a review. Int J Pept Res Ther. (2020) doi: 10.1007/s10989-020-10073-zLi G, He X, Zhang L, Ran Q, Wang J, Xiong A, et al. Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19. J Autoimmun. (2020) 112:102463. doi: 10.1016/j.jaut.2020.102463

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. View abstract. Royal jelly is a gelatinous substance produced by honey bees to feed the queen bees and their young. Here are 12 potential benefits of royal jelly. READ MORE Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. (2020) 395:1033–4. doi: 10.1016/S0140-6736(20)30628-0 WHO. Coronavirus disease 2019. (COVID-19) Situation Report – 88. (2020). Available online at: (accessed September 15, 2020).

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